General description

A cell-permeable xanthene compound that binds to Gβγ with high affinity (K_d ~400 nM derived from a surface plasma resonance binding study using Gβ₁γ₂) and blocks Gβγ-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lehmann, D.M., et al. 2008. Mol. Pharmacol.73, 410.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)